"Elaboración de una fórmula magistral tipificada para el tratamiento de infecciones bacterianas Tópicas"

Abstract

The titling work aimed to develop a typified master formula for treating topical bacterial infections. The research was of applied type and of experimental design, for which the raw materials were received; the base cream was elaborated by modifying the components and quantity of the anionic oil-in-water emulsion (O / W) described in the National form of the Spanish Agency of Medicines and Health Products (AEMPS) until finding the formulation with the best attributes, the active substance was added to it; clindamycin in concentrations of 1%, 1.5%, and 2%. Next, the topical magistral formulation's physicochemical and microbiological quality control followed the guidelines established in the INEN 2867 Standard (Ecuadorian standardization service) and the national form. Through the in vitro agar diffusion method, the cream's activity against Staphylococcus aureus, Staphylococcus epidermis, and Pseudomonas aureoginosa was evaluated. Regarding the results of the experimental work, obtained formulation 7 with 18g of cetyl alcohol, 6g of thiol V, 3 g of sodium lauryl sulfate, 2g of propylene glycol, 0.02g of propylparaben, 0.2 of methylparaben and 70.78 ml of water was ideal and met the organoleptic specifications. Physical, chemical, and microbiological. The three concentrations of the formulation showed antibacterial activity against S. aureus, S. epidermis, and P. aureginosa since the inhibition halos were found to be 34 mm - 36 mm, 11.5 mm-13mm, and 10 mm-12mm, respectively. It concludes that the concentration of the 1.5% formulation is the most appropriate to meet the desired therapeutic effect. It recommends evaluating the antibacterial activity quantitatively to establish the point amount at which it causes this effect.