Determinación de la influencia que posee la nicotina sobre los valores de hemoglobina glicosilada, mediante el uso de ratones Mus musculus Cepa Balb/c con hiperglucemia inducida por aloxano

Abstract

The determination of the influence of nicotine on glycosylated hemoglobin values, using Mus musculus strain BALB/c mice, with hyperglycemia induced by alloxan, was carried out in the Biotherium, Four experimental groups were established, three of which were given diabetes with the intraperitoneal administration of alloxan (175mg/kg), and two of which were given nicotine: 0. 04 g/kg and 0.20 g/kg, for fifteen days and glycemia was determined by Accu-chek. Intracardiac extraction was performed for the determination of glycosylated hemoglobin; finally the macroscopic and histopathological study showed important damages in the pancreas and kidneys. For the evaluation of the data obtained, the following statistical analyses were used: Anova, T-student and Tukey, through which it was confirmed that the level of nicotine is directly proportional to the level of glucose and this in turn to the glycosylated hemoglobin, as reflected by the resulting mean values of HbA1c equal to: White group 6%, control group with alloxan 7.43%, alloxan group with nicotine in low doses 9.23% and alloxan group with nicotine in high doses of 17.37% . This research aims to raise the awareness of diabetic patients who smoke so that they make every effort to quit smoking, and thus improve their quality of life.