Efecto Hipoglucemiante del Extracto Acuoso de Canela ( Cinnamomum Zeylanicum ), en Ratas (Rattus novergicus) con Hiperglicemia Inducida

Abstract

To test the hypoglycemic effect of cinnamon extract (Cinnamomum zeylanicim), in 18 rats (Rattus novergicus) with induced hyperglycemia, divided into six groups called: Standard; Positive Control; Negative Control; Group I - dose 0.2mL of cinnamon; Group II - dose 0.4mL of cinnamon and Group III - dose 0.6mL of cinnamon. It was carried out in the Biotherium of the School of Biochemistry and Pharmacy of ESPOCH, the diabetic animals were obtained by intraperitonial administration of alloxane (150mg/Kg weight) to determine the levels of glycemia was used the Human Analysis. The groups: I, II and III, received as treatment aqueous extract of cinnamon based on the bark, respectively at a concentration of 0.6g/kg; 1.2g/kg; 1.7g/kg. The negative control group received 1mg/kg of glimepiride (amaryl), the standard and passive control group only vehicle. The scientific analytical method was used and, for the analysis of the data obtained, the ANOVA (analysis of variance), T-student and Turkey 5% tests were used. After applying the aqueous cinnamon extract treatment, a decrease in blood glycemia was established, obtaining the following average values: Standard 92.7mg/dL; Positive control 375.0mg/dL; Negative control 89mg/dL; Group I 85mg/dL; Group II 41.5mg/dL; Group III 26.5mg/dL. Histopathological examination showed that there is no damage at the organ level (kidney and liver), concluding that cinnamon has no toxic effect to the organism. This research intends to be the basis for further studies of cinnamon, since it is concluded that it does have a hypoglycemic effect, being a great contribution to improve the quality of life of the diabetic patient.