Evaluación de protocolo de adquisición spect/ct para estudios cerebrales de diagnóstico de parkinson con el radiofármaco trodat-99mtc

Abstract

This research explored demonstrative advances in the three-dimensional representation of the striatum for use in medical imaging studies, with the aim of optimizing image acquisition and simulation of brain pathological conditions. The design and validation of a three-dimensional phantom model, the evaluation of activity ratios for a quality image and the optimization of acquisition protocols were addressed, in addition, a final design was achieved that not only satisfies current requirements, but also to facilitate the expansion of future studies, adjustments in the activity ratio between the phantom and the simulated striatum compensated for partial volume effects, providing images very similar to those from a study with a patient or volunteer when performing this study. In addition, the review of the acquisition parameters such as the matrix, the number of projections, zoom and the modification of the starting angle of the heads, in which a greater volumetric recovery and a better capture of activity could be visualized, improving thus the quality of the images and temporal efficiency. This study proposes a basis for continued improvement of neuroimaging practices and signals guidelines for future research