Optimización de los sistemas ITOPI y EMIS para determinar los efectos de dosis suministradas a partir de extractos de productos naturales, por medio del análisis y procesamiento de los parámetros de evaluación.

Abstract

The aim of this research study was to carry out the respective optimization processes in the consecutive stages of anxiolytic analysis, incorporating the Anxiolytic Lab evaluation system. Through the previous ITOPI & EMIS versions that incorporate image processing in order to quantify the Evaluation parameters and the compliance scripts with the statistical assumptions that were implemented in this research, the anxiolytic activity and the effects on the subject’s locomotion, as produced by the treatments, were determined. Through the statistical processing of the respective Test evaluation parameters: Dark Light Room, Elevated Cross Maze and Open Field, which are part of the unconditioned anxiolytic evaluation group. Consequently, the significant differences that exist between the treatments, as tested in the research, were obtained. It was concluded that the results of two research methods were valid, monitored by two Evaluators, by comparing statistical results versus the IBM SPSS Software. It is thus recommended to use a high-end processor due to the high computational load involved in executing the software and when performing the anxiolytic evaluation, utilizing the user manual to obtain information on the key points for the correct development of the system.