Elaboración y control de calidad de comprimidos antiparasitarios a base de Chenopodium ambrosioides, Thymus vulgaris y Carica papaya

Abstract

The objective of this research work was the manufacture and quality control of antiparasitic phytopharmaceutical tablets made from paico (Chenopodium ambrosioides), thyme (Thymus vulgaris) and papaya (Carica papaya) seeds, for which the different plantspecies were collectedand the respective quality control was performed, the different phytochemical screening tests were done to verify the presence of secondary metabolites with antiparasitic activity. The tablets were made using the wet granulation technique where 71.429g, 142.857g, 214.286g of Thyme, Papayaseedsand Paico respectively, 20g of Luviskol, 614ml of Water, 280g of Corn Starch, 250 of Lactose monohydrate, 10g of Avicel 112, 6g of Magnesium Stearate and 4g Talc. The mixture was tableted and tablets were obtained with the following quality parameters: flat round tablet appearance, smooth faces with greenish coloration and aromatic odor, 6% volatile content, disintegration time of 13.36 minutes, breaking strength 3.13 kilopond and absence of microbial growth. It was concluded that the antiparasitic tablets obtained complied with the specifications established by the USP-38 pharmacopoeia and were suitable for subsequent dispensing to 200 children who presented intestinal parasitosis in the San Luis parish of the Riobamba canton. For the replication of antiparasitic tablets, it is recommended to work with extracts to improve both their physical and organoleptic properties.