Formulación y control de calidad de un jarabe antiparasitario canino a base de Chenopodium ambrosioides (Paico).

Abstract

The main objective of this research study was to elaborate a canine antiparasitic syrup based on Chenopodium ambrosioides (paico). Most of the time human beings are exposed to multiple pathologies when coexisting with dogs because they are the main carrier of different pathogenic agents, among which were identified: gastroenteric nematodes, cestodes and protozoa, at present the pharmaceutical industry has developed new drugs to eradicate or eliminate internal parasites, however, they caused some secondary effect. A methodology with an experimental design and quantitative approach was used. For this purpose, quality control of the vegetable species was carried out, including tests such as: humidity, total ash, water soluble and insoluble in hydrochloric acid. In addition, the presence of secondary metabolites such as oils, fats, lactones, coumarins, triterpene-steroids, flavonoids, tannins, alkaloids, saponins and bitter principles was determined. Also for the elaboration of the syrup, it was divided into two stages: the oily and aqueous phase, and the final mixture, where 6 formulations were developed considering the concentration of sucrose and essential oil, and the organoleptic (color, odor, flavor, aspect), physicochemical (pH, density, viscosity) and microbiological parameters were measured. Based on the results obtained, formulation 6 proved to be the ideal formulation, which presented color, odor, flavor and pleasant appearance, with a pH of 4.44, a density of 1.304g/ml and viscosity of 110 cP. It was concluded that the antiparasitic syrup complied with the quality parameters established by the United States Pharmacopoeia USP42-Nf37 and the Spanish National Formulary, because it proved to be a safe and innocuous product, to be established as a natural syrup for canine use.