Estudio de Farmacovigilancia Dirigido a Pacientes con Artritis Reumatoide en el Instituto Ecuatoriano de Seguridad Social, IESS Riobamba

Abstract

The present investigation was carried out in the Hospital of the Ecuadorian Institute of Social Security (IESS) in the city of Riobamba in the area of Rheumatology, with the objective of implementing a Pharmacovigilance System within this area, managing to evaluate, understand and prevent Adverse Drug Reactions (ADR). Using the inductive-deductive, individualized and intensive Pharmacovigilance method, with the invaluable help of the doctor and the patients who were part of this study, as well as the talks, leaflets and telephone calls given to the patients. The study involved 30 patients diagnosed with Rheumatoid Arthritis between 30 and 72 years of age, in which 421 ADRs were detected at the beginning of the investigation, distributed as follows: 100% of the patients presented some ADR of Methotrexate followed by Corticoids with 90%, NSAIDs 73.33%, Omeprazole 60%, Adjuvants 36.66%. The ADRs were classified according to Lasagña's algorithm modified by Naranjo and collaborators. Of the 30 patients, 12, corresponding to 40%, were in the POSSIBLE category, followed by the DOUBTFUL category with 36.66%, PROBABLE 23.33%, and finally the PROVEN category with 0%. It was possible to implement the Pharmacovigilance system, thus reducing the percentage of patients who presented some type of ADR, improving the patient's quality of life and having effective pharmacotherapy for them. It is recommended that the Pharmaceutical Biochemist be taken into account as part of the health team to guarantee the health of the patients.