Elaboración y caracterización de microcápsulas mediante Gelificación Iónica externa, de la fracción alcaloidea de Ilex Guayusa con Alginato Sòdico, y su utilización en la formulación de una forma de dosificación sólida.

Abstract

The research consisted of developing microcapsules by using external ionic gelling of the alkaloid fraction of Ilex guayusa L., and its presentation as pharmaceutical form, in the Laboratory of Pharmaceutical Technology, School of Pharmacy and Biochemistry of the Escuela Superior Politécnica de Chimborazo. Used total alkaloids were obtained by percolation, and caffeine as a marker chemist using chromatography (HPLC) of the alkaloid fraction was identified. The microcapsules were prepared using sodium alginate, chloride calcium and total alkaloids as active ingredient, by infrared spectroscopy was ruled out the presence of interaction or formation of complexes between the coating and the active. Opted for soft gelatin capsules as pharmaceutical form where the microcapsules in dissolution studies showed to own a behavior of gastroprotection at pH 2.0 and modified release at pH 7,4. The methodology developed in this research is practical to perform, turning it into an effective system of preparation of microcapsules that comply with all the quality control tests. It is recommended a bioavailability study and the implementation of this methodology in the pharmaceutical industry.