Evaluación de la actividad cicatrizante de extractos de Bolsa de Pastor (Capsella bursa-pastoris) mediante el test de heridas inducidas en ratones (Mus musculus)

Abstract

The healing activity of sheepskin bag extracts (Capsella bursa-pastoris) was evaluated by the mouse injury test (Mus musculus), carried out in the Bioterio of the Faculty of Sciences of the Polytechnic School of Chimborazo, with the purpose Of contributing to the society new cicatrizantes alternatives of natural origin. Tests were carried out for the quality control of the plant and the extract used to evaluate the healing effect of the Capsella bursa-pastoris sheezer bag) in mice, 21 randomly divided mice were used in 7 groups of mice, to which 2cm long and 2mm deep wounds were applied. Different treatments were applied, evaluating the scarring time, length and width of the scar; The results obtained were analyzed using the Anova and Tukey tests with a 95% confidence interval. After their physical analysis of the scars samples were taken from the skins for subsequent microscopic analysis to measure the cellular regeneration of the wounds. A relative density of 0.9501 g / ml, pH 6.59, refractive index of 1.34 and 4.2% of total solids was obtained in the physical-chemical analysis of the hydroalcoholic extract. The vegetable has more tannins, flavonoids, saponins and triterpenic compounds. By means of the analysis of the applied tests it was found that the treatments with Lamoderm and hydroalcoholic extract to 80% have a similar healing effect, being the most effective ones. In conclusion, the hydroalcoholic extract of Capsella bursa-pastoris is effective in the healing process by topical use. It is recommended to apply this vegetable in the cosmetic industry for the elaboration of creams or gels with healing properties and emulsifiers due to its high content of saponins, being also usable in the food industry.