Elaboración, evaluación y control de calidad de una crema a base de pulpa de granadilla (Passiflora ligularis) para tratar la xerosis cutánea

Abstract

The objective of the study was the elaboration, evaluation and quality control of a cream based on Passiflora ligularis pulp in order to treat skin xerosis. The organoleptic, physical-chemical analysis and photochemical screening of the raw material was carried out, based on the parameters established according to the Ecuadorian and Colombian Technical Standards. Three formulations were prepared at concentrations of 1%, 3% and 5% of pulp, in order to evaluate the cream with greater hydration compared to the commercial one (Cp). The 25 patients were randomly divided into five groups, they were informed and then signed the consent. In group 1, the effectiveness of Cp was evaluated; in groups 2, 3 and 4 the formulations called FI, F2, F3 and group 5 the negative control; the treatment lasted 14 days, taking measurements on days 1, 5, 9 and 14 using the Skin Analyzer Mode-6. The results obtained indicated that formulation F2 has no significant difference compared to Cp due to the increase between the initial and final value during treatment, reaching values of Cp= 22% water (W) and 9.34% oil (O), and for the formulation F2 = 18.9% W and 5.7% O, in this sense it is stated that the F2 cream has moisturizing activity due to the P. ligularis pulp, the presence of flavonoids, alkaloids and reducing sugars, that attribute it therapeutic properties. Accelerated stability was evaluated for 12 weeks and microbiological control was performed based on the specifications of the Agencia Nacional de Regulación, Control y Vigilancia Sanitaria (ARCSA). Finally, it was concluded that the cream complies with the acceptability limits for its application according to the instructions for low-risk cosmetics published by the ARCSA. It is recommended to promote the use of P. ligularis in the cosmetic and pharmaceutical industry due to its multiple therapeutic properties.