Evaluación del marcador tumoral CA 15-3, por el método elisa y su posible relación con factores de riesgo en el personal femenino del Hospital Básico 11 BCB Galápagos, 2022

Abstract

The aim of this study was to evaluate the tumor marker CA 15-3, by mans of ELISA method and its possible relationship with risk factors in the female personnel of the Hospital Básico 11 BCB Galápagos. A survey was applied to 90 people in order to determine the biological risk factors, reproductive history and lifestyles, subsequently, blood samples were collected by venipuncture; these samples were processed in the Clinical Analysis Laboratory of Sciences College at ESPOCH; for the quantification of CA 15-3, a sandwich-type enzyme-linked immunosorbent assay (ELISA) was used. For the statistical analysis of both surveys and clinical tests, they were organized, classified and tabulated in a Microsoft Excel 2016 spreadsheet, calculating statistical measures such as averages and standard deviations; in addition, statistical software SPSS 22 was used to determine the correlation between the parameters analyzed. It is concluded that serum levels were lower than 37 U/ml, being this the normal reference value in women; it was also identified that the probability of breast cancer is higher in relation to the age at menopause, highlighting that when menopause occurs at an age younger than 50 years the value of the tumor marker 15-3 increases; this compared to cases when menopause did not occur in the study population or when it occurred at the age of 50; therefore, it is inferred that risk factors do not indicate everything, presenting one or even several of these factors does not mean that the person will have the disease, even many people who acquire the disease may not have these known risk factors.