Ormulación y control de calidad de un jarabe antiparasitario a base de semillas de papaya (Carica papaya) para uso canino (Canis lupus familiaris)

Abstract

The main objective of this research study was to formulate and perform quality control of an antiparasitic syrup based on papaya seeds(Carica papaya) for canine use (Canislupusfamiliaris), using an experimental design study with a quantitative approach. The study population was papaya seeds (Carica papaya). The analysis was carried out in three stages: the secondary metabolites present in papaya seeds (Carica papaya) were identified, the most suitable formulation for veterinary use was determined and the organoleptic, physicochemical, and microbiological characteristics of the ideal formulation were established. The results showed that Carica papaya presented in the ethereal extract: fats, alkaloids, and triterpenes, in the hydroalcoholic extract: amino acids, triterpenes, alkaloids, and flavonoids and the aqueous extract alkaloids and bitter principles were evidenced. Based on the organoleptic, physicochemical, and microbiological analyses, it was determined that formulations 6 and 7 were ideal, which presented an herbal odor, characteristic color,sweet taste and absence of particles. Asfor the physicochemical analyses, they had a pH of 4.42 and 4.26, density of 1.20 and 1.18 g/ml, refractive index of 1.36 and 1.35, and viscosity of 110 and 105 cP respectively. It was concluded that the antiparasitic syrup met the quality requirements of the United States Pharmacopoeia USP 42, showing adequate physicochemical properties and the absence of pathogenic microorganisms such as fungi, mesophilic aerobes, and Escherichia coli. It is recommended that, during the formulation of oral liquid solutions, aseptic standards be maintained to avoid the risk of cross-contamination.